Impaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure
Authors:
- Jeffrey FreitagJFJeffrey Freitag
- Kevin J. MartinKMKevin J. Martin
- Keith A. HruskaKHKeith A. Hruska
- Charles AndersonCACharles Anderson
- Mollie ConradesMCMollie Conrades
- Jack LadensonJLJack Ladenson
- Saulo KlahrSKSaulo Klahr
- Eduardo SlatopolskyESEduardo Slatopolsky
- 5 January 1978
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (1) , 29-32
Abstract
SECONDARY hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.1 , 2 Increased secretion has been accepted as the underlying mechanism responsible for the high levels of parathyroid hormone seen in uremic subjects. Multiple factors have been implicated in the pathogenesis of parathyroid hormone hypersecretion in chronic renal disease, including phosphate retention,3 impaired production of 1,25-dihydroxycholecalciferol4 leading to impaired intestinal calcium absorption,5 , 6 and skeletal resistance to the action of parathyroid hormone.7 , 8 In recent years, the importance of the kidney in the metabolism of parathyroid hormone has been recognized. Berson and Yalow9 demonstrated a prolonged . . .Keywords
This publication has 13 references indexed in Scilit:
- Effect of 25-hydroxycholecalciferol on calcium absorption in chronic renal diseaseKidney International, 1975
- Skeletal Resistance to Endogenous Parathyroid Hormone in Patients with Early Renal Failure. A Possible Cause for Secondary HyperparathyroidismThe Journal of Clinical Endocrinology & Metabolism, 1975
- Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease.Journal of Clinical Investigation, 1975
- Hyperparathyroidism and renal failureKidney International, 1973
- Study of intestinal absorption of calcium in patients with renal failureKidney International, 1973
- Skeletal Resistance to Parathyroid Hormone in Renal FailureAnnals of Internal Medicine, 1973
- TURNOVER OF ENDOGENOUS PARATHYROID HORMONE IN UREMIC PATIENTS AND THOSE UNDERGOING HEMODIALYSISASAIO Journal, 1972
- On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dogJournal of Clinical Investigation, 1971
- Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteNature, 1970
- Immunochemical Heterogeneity of Parathyroid Hormone in PlasmaThe Journal of Clinical Endocrinology & Metabolism, 1968