Role of A-chain in functioning of the active site of human α-thrombin
- 1 March 2008
- journal article
- review article
- Published by Pleiades Publishing Ltd in Biochemistry (Moscow)
- Vol. 73 (3) , 237-244
Abstract
This review summarizes current data suggesting that A-chain of the human α-thrombin molecule plays a role of allosteric effector in catalytic reactions with various substrates. Special attention is...Keywords
This publication has 57 references indexed in Scilit:
- Important Role of the Cys-191–Cys-220 Disulfide Bond in Thrombin Function and AllosteryJournal of Biological Chemistry, 2007
- Structure and interaction modes of thrombinBlood Cells, Molecules, and Diseases, 2006
- The Structure of Thrombin: A Janus-Headed ProteinaseSeminars in Thrombosis and Hemostasis, 2006
- An Overview of the Structure and Function of ThrombinSeminars in Thrombosis and Hemostasis, 2006
- A Natural Prothrombin Mutant Reveals an Unexpected Influence of A-chain Structure on the Activity of Human α-ThrombinJournal of Biological Chemistry, 2004
- A player of many parts: The spotlight falls on thrombin's structureThrombosis Research, 1993
- The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationshipsProtein Science, 1992
- Thrombin structure and functionBlood Coagulation & Fibrinolysis, 1991
- Thrombin Active-Site RegionsSeminars in Thrombosis and Hemostasis, 1986
- Mechanism of action of thrombin on fibrinogen: NMR evidence for a .beta.-bend at or near fibrinogen a.alpha. Gly(P5)-Gly(P4)Biochemistry, 1985