Relationship between oestrogen-receptor content and histological grade in human primary breast tumours

Authors:
  • PMP V Maynard
    P V Maynard
  • CDC J Davies
    C J Davies
  • RBR W Blamey
    R W Blamey
  • CEC W Elston
    C W Elston
  • JJJ Johnson
    J Johnson
  • KGK Griffiths
    K Griffiths

Abstract
A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only in women defined as post-menopausal. Data on early recurrence of disease indicate a worse prognosis for women in whom primary tumours are ER-.