No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis
Authors:
- Masato EnariMEMasato Enari
- Shigekazu NagataSNShigekazu Nagata
- 12 September 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 351 (3) , 311-313
Abstract
Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)‐induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas‐mediated apoptosis and show that they are not able to block Fas‐mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)‐dependent and ‐independent mechanisms which lead to apoptosis do exist. Fas‐mediated apoptosis probably proceeds via a ROI‐independent pathway.Keywords
This publication has 15 references indexed in Scilit:
- Function and Activation of NF-kappaB in the Immune SystemAnnual Review of Immunology, 1994
- Oxidative stress as a mediator of apoptosisImmunology Today, 1994
- Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor familyCell, 1993
- Bcl-2 inhibition of neural death: decreased generation of reactive oxygen speciesScience, 1993
- Bcl-2 functions in an antioxidant pathway to prevent apoptosisCell, 1993
- A novel domain within the 55 kd TNF receptor signals cell deathCell, 1993
- Effect of bcl-2 on Fas antigen-mediated cell death.The Journal of Immunology, 1993
- Social controls on cell survival and cell deathNature, 1992
- The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosisCell, 1991
- Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.Journal of Clinical Investigation, 1984