Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions

Authors:
  • GCGuerline Clerzius
    Guerline Clerzius
  • ADAïcha Daher
    Aïcha Daher
  • CMCarlos Melendez-Peña
    Carlos Melendez-Peña
  • SDSylvanne Daniels
    Sylvanne Daniels
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Abstract
The double-stranded (ds) RNA binding proteins, TRBP and PACT bind the interferon-induced protein kinase PKR and dsRNA. TRBP inhibits, whereas PACT activates PKR. They have two dsRNA binding domains...