Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal deposit formation

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Abstract
Significance: This study demonstrates that the extracellular protein human vitronectin (Vn) is able to bind both soluble calcium ions and mineralized hydroxyapatite with chemical specificity. The results have important implications for the normal functions of Vn and its role in the formation of plaques associated with age-related macular degeneration, Alzheimer’s disease, atherosclerosis, and other degenerative disorders. The molecular basis for plaque formation in these pathologies is unknown. The present findings shed light on this important process, advance our understanding of the mechanisms of abnormal plaque formation, and introduce a target with potential for developing diagnostic, preventive, or therapeutic approaches.
Funding Information
  • HHS | NIH | National Institute of General Medical Sciences (118186)

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