Abstract
The urine (85% ± 6% of the dose in 12 hours), but little ORG NC 45 appeared in the urine (3.5% ± 1.1 % in 12 hours). Biliary excretion accounted for 46% ± 4% of the ORG NC 45 dose in 7 hours, but only 7.5% ± 5.3% of an injected dose of pancuronium appeared in the bile. Thus, it appears that ORG NC 45 (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound). The different biodisposition of these two compounds may be due to the greater lipophilicity and concomitant enhanced permeability into the hepatocyte of ORG NC 45. We conclude that in the rat elimination of pancuronium is primarily via the kidney whereas elimination of ORG NC 45 is dependent on nonrenal mechanisms. This study was supported by the Anesthesia-Pharmacology Research Foundation, ORGanon, Inc., Oss (Holland) and National Institutes of Health grant GM-26043. Reprint requests to Dr. Miller, Department of Anesthesia, S-436, University of California, San Francisco, School of Medicine, San Francisco, CA 94143. Accepted for publication November 24, 1981. © 1982 International Anesthesia Research Society...