Synthesis and antibacterial activity of 1‐(2,4‐dichlorobenzoyl)‐4‐substituted thiosemicarbazides, 1,2,4‐triazoles and their methyl derivatives

Authors:
Publisher website
Google Scholar
Abstract
A series of 1‐(2,4‐dichlorobenzoyl)thiosemicarbazides, s‐triazoles and their methyl derivatives have been synthesised by condensation of 2,4‐dichlorobenzoyl hydrazine with aryl isothiocyanates. Subsequent ring closure of the substituted thiosemicarbazides yielded the s‐triazoles, and reaction with methyl iodide resulted methyl derivatives. All the compounds were subjected to in vitro testing against two gram‐positive and two gram‐negative bacteria. Antibacterial activity was found to be moderate to good in most of the compounds.