Improved outcomes after low‐concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

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Abstract
Objectives/Hypothesis: We aimed to evaluate the effectiveness of low‐concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis.Study Design: This was a randomized, prospective, active‐controlled study.Methods: This study investigated the effectiveness of 4 weeks of low‐concentration hypochlorous irrigation by analyzing five categorized subjective symptoms and x‐ray findings in pediatric patients with rhinosinusitis. Thirty‐seven patients were enrolled, and 26 patients successfully completed the study.Results: Total symptom scores significantly improved with both HOCl and normal saline nasal irrigation, but there was no difference between the two groups. X‐ray scores also improved in both groups; improvement was much greater in the HOCl group than the placebo group.Conclusions: Nasal irrigation with HOCl is an effective adjuvant treatment compared to isotonic normal saline for pediatric sinusitis.Level of Evidence: 1b Laryngoscope, 126:791–795, 2016

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