Synthesis and Antimicrobial Activity of Some 2-(Benzo[ d ]oxazol/benzo[ d ]imidazol-2-ylthio)- N -(9 H -fluoren-9-yl)acetamide Derivatives
Authors:
- 30 January 2007
- journal article
- research article
- Published by Taylor & Francis in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 182 (3) , 639-646
Abstract
Some 2-(benzo[d]oxazol/benzo[d]imidazol-2-ylthio)-N-(9H-fluoren-9-yl)acetamide derivatives were synthesized by reacting 9-(chloroacetylamino)fluorene with benzo[d]oxazol/benzo[d]imidazol-2-thiole in acetone in the presence of K2CO3. Chemical structures of the compounds were elucidated by 1H NMR spectroscopy and FAB+ mass spectrometry. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans, and Candida glabrata were investigated, and significant activity was observed.Keywords
This publication has 19 references indexed in Scilit:
- Antimicrobial Use and the Emergence of Antimicrobial Resistance withStreptococcus pneumoniaein the United StatesClinical Infectious Diseases, 2001
- The rise and fall of antimicrobial resistanceTrends in Microbiology, 2001
- Development of Antimicrobial Agents in the Era of New and Reemerging Infectious Diseases and Increasing Antibiotic ResistanceJAMA, 2001
- Emergence of Methicillin-Resistant Staphylococcus aureus with Intermediate Glycopeptide ResistanceDrugs, 2001
- Vancomycin-Resistant EnterococciClinical Microbiology Reviews, 2000
- Antimicrobial Resistance in Gram‐Positive Bacteria: The Myth of the MICPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1999
- The Challenge of Antibiotic ResistanceScientific American, 1998
- Antibiotic resistanceDrugs of Today, 1998
- Antibiotic Resistance: Proceedings of a Symposium Held on 12 July 1996 at the University of SouthamptonJournal of Medical Microbiology, 1997
- New Directions in Antibacterial ResearchJournal of Medicinal Chemistry, 1996