Equilibrium Values of Measures of Population Subdivision for Stepwise Mutation Processes
Open Access
- 1 April 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 142 (4) , 1357-1362
Abstract
Expected values of Wright'sF-statistics are functions of probabilities of identity in state. These values may be quite different under an infinite allele model and under stepwise mutation processes such as those occurring at microsatellite loci. However, a relationship between the probability of identity in state in stepwise mutation models and the distribution of coalescence times can be deduced from the relationship between probabilities of identity by descent and the distribution of coalescence times. The values of FIS and FST can be computed using this property. Examination of the conditional probability of identity in state given some coalescence time and of the distribution of coalescence times are also useful for explaining the properties of FIS and FST at high mutation rate loci, as shown here in an island model of population structure.Keywords
This publication has 10 references indexed in Scilit:
- Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size.Molecular Biology and Evolution, 1995
- Conservation of Human Chromosome 13 Polymorphic Microsatellite (CA)n Repeats in ChimpanzeesGenomics, 1994
- Mutational processes of simple-sequence repeat loci in human populations.Proceedings of the National Academy of Sciences, 1994
- High resolution of human evolutionary trees with polymorphic microsatellitesNature, 1994
- Mutation of human short tandem repeatsHuman Molecular Genetics, 1993
- Inbreeding coefficients and coalescence timesGenetics Research, 1991
- Group selection for a polygenic behavioral trait: estimating the degree of population subdivision.Proceedings of the National Academy of Sciences, 1984
- Wandering distributions and the electrophoretic profileTheoretical Population Biology, 1975
- A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite populationGenetics Research, 1973
- Effective number of alleles in a subdivided populationTheoretical Population Biology, 1970