Differentiation of a cell line of myeloid leukemia
Author:
- 1 December 1969
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 74 (3) , 223-234
Abstract
A cell line was established in vitro from a spontaneous myeloid leukemia of SL strain mice. This cell line was cytologically identified as myeloblast, and its normal differentiation appeared to be completely blocked in mass culture. When the line cells were seeded in soft agar with a conditioned medium from normal cells, either macrophages or neutrophil granulocytes appeared from a single clone. The rate of formation of colonies containing differentiated cells always increased with an increase in the concentration of conditioned medium. The conditioned medium from this line cell was not as effective as was that from normal cells in inducing differentiation.Keywords
This publication has 10 references indexed in Scilit:
- The stimulation of tumor cell growth by a substance produced by normal and tumor cellsJournal of Cellular Physiology, 1969
- FEEDBACK INHIBITION OF THE DEVELOPMENT OF MACROPHAGE AND GRANULOCYTE COLONIES, II. INHIBITION BY GRANULOCYTESProceedings of the National Academy of Sciences, 1969
- Production of the inducer for macrophage and granulocyte colonies by leukemic cellsJournal of Cellular Physiology, 1968
- The continued requirement for inducer for the development of macrophage and granulocyte coloniesJournal of Cellular Physiology, 1968
- Feedback inhibition of the development of macrophage and granulocyte colonies. I. Inhibition by macrophage.Proceedings of the National Academy of Sciences, 1967
- The induction of clones of normal mast cells by a substance from conditioned mediumExperimental Cell Research, 1966
- In vitro control of the development of macrophage and granulocyte colonies.Proceedings of the National Academy of Sciences, 1966
- THE GROWTH OF MOUSE BONE MARROW CELLS IN VITROImmunology & Cell Biology, 1966
- The cloning of normal “Mast” cells in tissue cultureJournal of Cellular and Comparative Physiology, 1965
- HISTOCHEMICAL DIFFERENTIATION DURING NEUTROPHIL DEVELOPMENT AND MATURATION*Annals of the New York Academy of Sciences, 1964