Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum’s Acid and Aza-Michael Strategies

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Abstract
In this study, we developed two complementary synthetic routes to novel piperidine- and azetidine-containing 2,3-disubstituted propanoic acid derivatives as heterocyclic amino acid building blocks. The strategy employs ketone- and carboxylic acid-derived Meldrum’s acid intermediates, which are converted into common α,β-unsaturated methyl esters through methanolysis; they are subsequently diversified via DBU-promoted aza-Michael addition with saturated cyclic amines and aromatic NH-heterocycles. The ketone-derived approach provided piperidine-containing derivatives in 35–89% yield and the corresponding azetidine analogues in 61–92% yield, whereas the complementary acid-derived route afforded regioisomeric products in 59–85% and 61–89% yield, respectively. Both synthetic sequences tolerated a broad range of nitrogen nucleophiles, and no alternative regioisomeric aza-Michael products were detected for heterocycles containing multiple nitrogen atoms. The structures of the synthesized compounds were established via 1H, 13C, 15N, and 19F NMR spectroscopy together with HRMS, including detailed multidimensional NMR analysis of representative products. The developed methodology provides efficient access to structurally diverse heterocyclic propanoic acid derivatives and expands the repertoire of amino acid building blocks available for peptide chemistry, medicinal chemistry, and DNA-encoded library synthesis.
Funding Information
  • Vipergen ApS

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