Prostaglandins in Severe Congestive Heart Failure

Authors:
  • VDVictor J. Dzau
    Victor J. Dzau
  • MPMilton Packer
    Milton Packer
  • LLLeonard S. Lilly
    Leonard S. Lilly
  • SSStephen L. Swartz
    Stephen L. Swartz
  • NHNorman K. Hollenberg
    Norman K. Hollenberg
  • GWGordon H. Williams
    Gordon H. Williams
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Abstract
To determine whether prostaglandins are involved in circulatory homeostasis in congestive heart failure, we measured plasma levels of the metabolites of vasodilator prostaglandins I2 and E2 in 15 patients with severe chronic heart failure. Mean circulating levels of both metabolites were 3 to 10 times higher than those in normal subjects. Plasma levels of both metabolites correlated directly with plasma renin activity and plasma angiotensin II concentrations (r = 0.64 and 0.84, respectively). Individual serum sodium concentrations were inversely correlated with levels of prostaglandin E2 metabolites (r = -0.92, P-5, P<0.001), whereas the 14 patients with a normal serum sodium concentration had no significant hemodynamic changes.

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