Gestational Diabetes Mellitus Subtypes and Maternal Cardiometabolic Outcomes 10–14 Years After Delivery

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Abstract
OBJECTIVE: The association of gestational diabetes mellitus (GDM) subtypes with maternal cardiometabolic health is not known. We examined whether GDM subtypes were differentially associated with cardiometabolic health 10–14 years after delivery. RESEARCH DESIGN AND METHODS: We used data from the prospective Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study. The exposure was GDM subtype (insulin deficient, insulin resistant, mixed defect, unclassified). The outcomes were prediabetes or diabetes and, secondarily, hypertension, dyslipidemia, metabolic syndrome, and predicted cardiovascular disease. RESULTS: Of 4,693 women, 3.0% had insulin-deficient, 9.0% insulin-resistant, 1.6% mixed-defect, and 0.7% unclassified GDM. Compared with no GDM, all GDM subtypes except unclassified were associated with higher risk of prediabetes or diabetes (adjusted risk ratios 2.14–2.88), metabolic syndrome, and predicted cardiovascular disease. Only insulin-resistant GDM was associated with dyslipidemia. CONCLUSIONS: All GDM subtypes were associated with an increased risk of prediabetes or diabetes, metabolic syndrome, and high predicted cardiovascular disease 10–14 years after delivery.
Funding Information
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • American Diabetes Association
  • Care Innovation and Community Improvement Program at The Ohio State University
  • National Heart, Lung, and Blood Institute (HL161514)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development

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