Q10-triggered facial vitiligo
- 2 December 2013
- journal article
- Published by Wiley in British Journal of Dermatology
- Vol. 169 (6) , 1333-1336
Abstract
NoBackground\ud \ud Generation and accumulation of reactive oxygen/nitrogen species in the epidermis of patients with vitiligo has been widely documented. Moreover, semiquinone radical-mediated sensitivity has been shown in blood lymphocytes of these patients.\ud Objectives\ud \ud To determine the possible mechanism behind Q10-induced facial vitiligo.\ud Methods\ud \ud This was a clinical assessment supported by in vivo Fourier transform–Raman spectroscopy and repigmentation.\ud Results\ud \ud Topical Q10 application generated hydrogen peroxide (H2O2) leading in turn to facial vitiligo in susceptible individuals. Proof of the basic result stemmed from reduction of epidermal H2O2 by using narrowband ultraviolet B-activated propseudocatalase PC-KUS in association with cessation of depigmentation and repigmentation of the lost skin colour.\ud Conclusions\ud \ud Over-the-counter availability of Q10-containing topical formulations can be harmful to individuals susceptible to vitiligoKeywords
This publication has 19 references indexed in Scilit:
- Enhanced DNA binding capacity on up‐regulated epidermal wild‐type p53 in vitiligo by H 2 O 2 ‐mediated oxidation: a possible repair mechanism for DNA damageThe FASEB Journal, 2009
- From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC‐KUS in 71 children with vitiligoInternational Journal of Dermatology, 2008
- Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cellsFree Radical Biology and Medicine, 2008
- Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?Experimental Dermatology, 2008
- Estrogens Can Contribute to Hydrogen Peroxide Generation and Quinone-Mediated DNA Damage in Peripheral Blood Lymphocytes from Patients with VitiligoJournal of Investigative Dermatology, 2006
- Biological response of human diploid keratinocytes to quinone-producing compounds: role of NAD(P)H:quinone oxidoreductase 1The International Journal of Biochemistry & Cell Biology, 2005
- Melanin Pigmentation in Mammalian Skin and Its Hormonal RegulationPhysiological Reviews, 2004
- Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.Free Radical Biology and Medicine, 2001
- HUMAN IN VIVO AND IN VITRO HYDROQUINONE TOPICAL BIOAVAILABILITY, METABOLISM, AND DISPOSITIONJournal of Toxicology and Environmental Health, Part A, 1998
- The participation of coenzyme Q in free radical production and antioxidationFree Radical Biology and Medicine, 1990