Short-Term Treatment of Idiopathic Precocious Puberty with a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone

Authors:
  • FCFlorence Comite
    Florence Comite
  • GCGordon B. Cutler
    Gordon B. Cutler
  • JRJean Rivier
    Jean Rivier
  • WVWylie W. Vale
    Wylie W. Vale
  • DLD. Lynn Loriaux
    D. Lynn Loriaux
  • WCWilliam F. Crowley
    William F. Crowley
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Abstract
The uncoupling of pituitary stimulation and response observed in adults during administration of the luteinizing hormone-releasing hormone analogue, D-Trp6-Pro9-NEt-LHRH (LHRHa) suggested that this drug might be useful in treating precocious puberty. We treated five girls with idiopathic precocious puberty (ages two to eight) for eight weeks with daily subcutaneous injections of LHRHa. The patients had Tanner II to IV pubertal development, advanced bone age, an estrogen effect on vaginal smear, measurable basal gonadotropin levels with pulsed nocturnal secretion, and a pubertal gonadotropin response to LHRH. Irregular vaginal bleeding was present in three patients. LHRHa significantly decreased basal (Pa can be adequately assessed. (N Engl J Med. 1981; 305:1546–50.)

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