PMP–diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis
Open Access
- 15 November 2019
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 55 (96) , 14502-14505
Abstract
ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin.Keywords
Funding Information
- National Institute of General Medical Sciences (R01GM129793)
- H2020 European Research Council (NCB-TNT (339367))
- Biotechnology and Biological Sciences Research Council (BB/P018017/1)
This publication has 35 references indexed in Scilit:
- Crystal structure of Glutamate1-semialdehyde aminotransferase from Bacillus subtilis with bound pyridoxamine-5′-phosphateBiochemical and Biophysical Research Communications, 2010
- Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivationMolecular BioSystems, 2010
- A simple and efficient expression and purification system using two newly constructed vectorsProtein Expression and Purification, 2009
- Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure databaseGenome Biology, 2007
- Protein structure database search and evolutionary classificationNucleic Acids Research, 2006
- Protein database searches using compositionally adjusted substitution matricesThe FEBS Journal, 2005
- Crystal structures of dialkylglycine decarboxylase inhibitor complexes 1 1Edited by R. HuberJournal of Molecular Biology, 1999
- Characterization of RecombinantEschericha coli5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase: Analysis of Enzymatic Activity and Substrate SpecificityBiochemical and Biophysical Research Communications, 1996
- The pathway ofD-cycloserine biosynthesis inStreptomyces garyphalusArchives of Microbiology, 1982
- COMPETITIVE INHIBITION OF ENZYMATIC REACTIONS BY OXAMYCINJournal of the American Chemical Society, 1960