Small Molecule Effectors of Myosin Function
- 26 May 2020
- book chapter
- Published by Springer Nature
- Vol. 1239, 61-84
Abstract
Several small molecule effectors of myosin function that target the motor domains of myosin classes I, II, V, and VI have been identified. Four distinct binding sites in the myosin motor domain have been reported with unique properties and mechanisms of action. This chapter describes the structural basis and activities of known small molecule effectors that allosterically target the myosin motor domain.Keywords
This publication has 142 references indexed in Scilit:
- Properties of blebbistatin for cardiac optical mapping and other imaging applicationsPflügers Archiv - European Journal of Physiology, 2012
- Kinetic properties and small‐molecule inhibition of human myosin‐6FEBS Letters, 2012
- Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680VJournal of Biological Chemistry, 2011
- Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor ActivityJournal of Biological Chemistry, 2011
- Engineering neuronal growth cones to promote axon regeneration over inhibitory moleculesProceedings of the National Academy of Sciences, 2011
- A Myosin V Inhibitor Based on Privileged Chemical ScaffoldsAngewandte Chemie International Edition, 2010
- Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working strokeProceedings of the National Academy of Sciences, 2010
- Structural Basis for the Regulation of Muscle Contraction by Troponin and TropomyosinJournal of Molecular Biology, 2008
- Rho-linked genes and neurological disordersPflügers Archiv - European Journal of Physiology, 2007
- Multicomponent therapeutics for networked systemsNature Reviews Drug Discovery, 2005