Melanocortin Receptors: Identification and Characterization by Melanotropic Peptide Agonists and Antagonists
Authors:
- 1 October 1996
- journal article
- Published by Wiley in Pigment Cell Research
- Vol. 9 (5) , 213-234
Abstract
Hormones are chemical messengers released from cells to act on and control the activity of other cells. Hormonal ligands initiate their actions by interacting with receptive substances (Langley, 1906) of the target cells. These receptors are proteins that are either integral components of the cell membrane or are localized cytoplasmically within cells. Ligand-receptor interaction results in either the stimulation or inhibition of cellular activity. Since most hormones bind rather specifically to receptors possessed by their target cells, labeling of hormonal ligands can be utilized to identify and localize cells within an animal. In this report we discuss what is presently known about melanocortin receptors (MCRs) as studied by the use of labeled melanotropic peptide ligands.Keywords
This publication has 102 references indexed in Scilit:
- Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtypeNeurochemical Research, 1995
- Molecular Cloning, Expression, and Characterization of a Fifth Melanocortin ReceptorBiochemical and Biophysical Research Communications, 1994
- Molecular Cloning and Characterisation of the Rat Fifth Melanocortin ReceptorBiochemical and Biophysical Research Communications, 1994
- Hormonal Regulation of Melanogenesis in Mouse Melanoma and in Human MelanocytesAnnals of the New York Academy of Sciences, 1993
- Up-regulation of MSH receptors by MSH in cloudman melanoma cellsBiochemical and Biophysical Research Communications, 1992
- Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopyJournal of Molecular Biology, 1990
- Regulatory factors that determine growth and phenotype of normal human melanocytes*1Experimental Cell Research, 1988
- Receptors for .beta.-melanocyte-stimulating hormone exhibit positive cooperativity in synchronized melanoma cellsBiochemistry, 1988
- Ultraviolet radiation directly induces pigment production by cultured human melanocytesJournal of Cellular Physiology, 1987
- Implications of the X-ray structure of deamino-oxytocin to agonist/antagonist-receptor interactionsTrends in Pharmacological Sciences, 1987