Leptin receptor polymorphisms and lung function decline in COPD

Authors:
Publisher website
Google Scholar
Abstract
Only a fraction of all smokers develop chronic obstructive pulmonary disease (COPD), suggesting a large role for genetic susceptibility. The leptin receptor (LEPR) is present in human lung tissue and may play a role in COPD pathogenesis. The present study examined the association between genetic variants in theLEPRgene and lung function decline in COPD.In total, 429 European Americans were randomly selected from the National Heart Lung and Blood Institute Lung Health Study. 36 single nucleotide polymorphisms (SNPs) inLEPRwere genotyped using the IlluminaTMGoldenGate platform (Broad Institute, Cambridge, MA, USA). Mean annual decline in forced expiratory volume in 1 s % predicted over the 5-yr period was calculated using linear regression. Linear regression models were also used to adjust for potential confounders. In addition,in vivoexpression of the receptor gene was assessed with immunohistochemistry on lungs from smoke-exposed inbred mice.We identified significant associations (pLEPRgene significantly associated with lung function decline in a population of smokers with COPD. Our results support a role forLEPRas a novel candidate gene for COPD.

This publication has 39 references indexed in Scilit: