Testicular microlithiasis imaging and follow-up: guidelines of the ESUR scrotal imaging subcommittee
Authors:
- Jonathan RichenbergJRJonathan Richenberg
- Jane BelfieldJBJane Belfield
- Parvati RamchandaniPRParvati Ramchandani
- Laurence RocherLRLaurence Rocher
- Simon FreemanSFSimon Freeman
- Athina C. TsiliATAthina C. Tsili
- Faye CuthbertFCFaye Cuthbert
- Michal StudniarekMSMichal Studniarek
- Michele BertolottoMBMichele Bertolotto
- Ahmet Tuncay TurgutATAhmet Tuncay Turgut
- Vikram DograVikram Dogra
- Lorenzo E. DerchiLDLorenzo E. Derchi
- 15 October 2014
- journal article
- practice guideline
- Published by Springer Nature in European Radiology
- Vol. 25 (2) , 323-330
Abstract
The subcommittee on scrotal imaging, appointed by the board of the European Society of Urogenital Radiology (ESUR), have produced guidelines on imaging and follow-up in testicular microlithiasis (TML). The authors and a superintendent university librarian independently performed a computer-assisted literature search of medical databases: MEDLINE and EMBASE. A further parallel literature search was made for the genetic conditions Klinefelter’s syndrome and McCune-Albright syndrome. Proposed guidelines are: follow-up is not advised in patients with isolated TML in the absence of risk factors (see Key Points below); annual ultrasound (US) is advised for patients with risk factors, up to the age of 55; if TML is found with a testicular mass, urgent referral to a specialist centre is advised. Consensus opinion of the scrotal subcommittee of the ESUR is that the presence of TML alone in the absence of other risk factors is not an indication for regular scrotal US, further US screening or biopsy. US is recommended in the follow-up of patients at risk, where risk factors other than microlithiasis are present. Risk factors are discussed and the literature and recommended guidelines are presented in this article. • Follow up advised only in patients with TML and additional risk factors. • Annual US advised for patients with risk factors up to age 55. • If TML is found with testicular mass, urgent specialist referral advised. • Risk factors – personal/ family history of GCT, maldescent, orchidopexy, testicular atrophy.Keywords
This publication has 38 references indexed in Scilit:
- Normative Values for Testicular Volume Measured by Ultrasonography in a Normal Population from Infancy to AdolescenceHormone Research in Paediatrics, 2011
- Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotypeEndocrine-Related Cancer, 2010
- Testicular dysgenesis syndrome: foetal origin of adult reproductive problemsClinical Endocrinology, 2009
- Younger age-at-diagnosis for familial malignant testicular germ cell tumorFamilial Cancer, 2009
- Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relativesBritish Journal of Cancer, 2008
- Testicular Dysgenesis Syndrome and the Estrogen Hypothesis: A Quantitative Meta-AnalysisEnvironmental Health Perspectives, 2008
- Testicular microlithiasis as a familial risk factor for testicular germ cell tumourBritish Journal of Cancer, 2007
- McCune-Albright SyndromeJournal of Pediatric Endocrinology and Metabolism, 2007
- Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: Evidence from 20 adult patients with signs of maldevelopment of the testisAPMIS, 2003
- Testicular Microlithiasis: Histologic and Immunohistochemical Findings in 11 Pediatric CasesPediatric and Developmental Pathology, 2002