cDNA and deduced amino acid sequence of human PK‐120, a plasma kallikrein‐sensitive glycoprotein
Authors:
- 3 January 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 357 (2) , 207-211
Abstract
PK‐120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK‐120 mRNA. The deduced amino sequence of PK‐120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK‐120 may be a precursor of a bioactive peptide. Most interestingly, PK‐120 showed significant sequence identities to heavy chains (HCs) of the inter‐α‐trypsin inhibitor (ITI) superfamily.Keywords
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