To develop electrocatalysts that are both highly active and cost-effective is essential for advancing the hydrogen evolution reaction (HER) in water splitting applications. Herein, we report Ni@PtIrRhCo nanodendrites (NDs), synthesized through a simple oil bath method. The obtained Ni@PtIrRhCo NDs exhibit a dendritic structure composed of assembled branched nanocrystals. Benefiting from their multielement composition and structural features, the catalyst demonstrates superior HER activity in both alkaline and acidic condition. Specifically, in 1.0 M KOH and 0.5 M H2SO4, the overpotential required to reach 10 mA cm-2 is merely 24 mV and 51 mV, respectively, outperforming most previously reported similar electrocatalysts. Moreover, the Ni@PtIrRhCo NDs exhibit outstanding catalytic stability under prolonged operation. This study offers a straightforward yet effective route toward the development of advanced HER electrocatalysts featuring both high activity and robust stability.