Role of exercise-induced hepatokines in metabolic disorders
- 1 July 2019
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 317 (1) , E11-E24
Abstract
The health-promoting effects of physical activity to prevent and treat metabolic disorders are numerous. However, the underlying molecular mechanisms are not yet completely deciphered. In recent years, studies have referred to the liver as an endocrine organ, since it releases specific proteins called hepatokines. Some of these hepatokines are involved in whole body metabolic homeostasis and are theorized to participate in the development of metabolic disease. In this regard, the present review describes the role of Fibroblast Growth Factor 21, Fetuin-A, Angiopoietin-like protein 4, and Follistatin in metabolic disease and their production in response to acute exercise. Also, we discuss the potential role of hepatokines in mediating the beneficial effects of regular exercise and the future challenges to the discovery of new exercise-induced hepatokines.Keywords
This publication has 177 references indexed in Scilit:
- Angiopoietin-like 4 (Angptl4) Protein Is a Physiological Mediator of Intracellular Lipolysis in Murine AdipocytesJournal of Biological Chemistry, 2012
- Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese womenClinical Endocrinology, 2011
- Serum fetuin‐A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetesClinical Endocrinology, 2011
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesityProceedings of the National Academy of Sciences, 2009
- Inhibition of myostatin with emphasis on follistatin as a therapy for muscle diseaseMuscle & Nerve, 2009
- FGF21 is an Akt‐regulated myokineFEBS Letters, 2008
- HSP72 protects against obesity-induced insulin resistanceProceedings of the National Academy of Sciences, 2008
- Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese MiceCell Metabolism, 2008
- Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21Journal of Biological Chemistry, 2007
- Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytesBiochemical and Biophysical Research Communications, 2006