Epsilon Aminocaproic Acid for the Prevention of Delayed Postoperative Bleeding in Retired Racing Greyhounds Undergoing Gonadectomy

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Abstract
Objective: To evaluate the effects of epsilon aminocaproic acid (EACA) on the prevalence of postoperative bleeding in retired racing Greyhounds (RRG), and to assess its effects on selected thrombelastography (TEG) and fibrinolysis variables.Study Design: Double‐blinded, prospective, randomized study.Methods: 100 RRG had elective ovariohysterectomy or orchiectomy and were administeredEACAor placebo for 3 days after surgery.TEGvariables were analyzed preoperatively and 24, 48, and 72 hours after surgery.Results: Thirty percent (15/50) ofRRGin the placebo group had delayed postoperative bleeding starting 36–48 hours after surgery compared with 10% (5/50) in theEACAgroup (P= .012). On theTEGvariables, the slopes forRandKtime were significantly different between treatment groups (P<.05); theRandKtime decreased over time in the EACA group after surgery whereas they increased in the placebo group. The angle, maximal amplitude (MA), andGslopes were also significantly different between treatment groups (P= .001, .001, and .006, respectively). The angle,MA, andGincreased postoperatively over time in theEACAgroup and decreased in the placebo group. All these changes are supportive of hypercoagulability associated withEACAadministration.Conclusion: Postoperative administration ofEACAsignificantly decreased the prevalence of postoperative bleeding inRRGundergoing surgery by increasing the clot strength.

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