Single molecule level detection of allophycocyanin by surface enhanced resonance Raman scattering

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Abstract
Single molecule level detection of the near-infrared fluorescent protein allophycocyanin (APC) has been achieved using surface enhanced resonance Raman scattering (SERRS). The detection limit using the peak height of the 440 cm−1 band was 1 × 10−13 mol l−1, compared to 2 × 10−12 mol l−1 for the fluorescence peak at 660 nm.

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