In-Vitro-5-Lipoxygenasehemmung durchEclipta albaExtrakte und das Coumestan-Derivat Wedelolacton

Authors:
  • HWH. Wagner
    H. Wagner
  • BFB. Fessler
    B. Fessler
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Abstract
In the search for potent and selective 5-lipoxygenase-inhibitors, extracts of medicinal plants were screened for their potency of inhibiting the formation of inflammatory acting products of arachidonic acid metabolism using a porcine-leukocytes test system. The coumestan derivative wedelolactone isolated from Eclipta alba (L.) Hassk. and Wedelia calendulacea Less. has been found as a potent and selective 5-lipoxygenase-inhibitor with an IC50 of 2,5 µMol. As found by chemoluminescence, wedelolactone inhibits 5-lipoxygenase by an oxygen radical scavenger mechanism.