Biological Properties of 16α-Hydroxyestrone: Implications in Estrogen Physiology and Pathophysiology*
Authors:
- Jack FishmanJFJack Fishman
- Charles MartucciCMCharles Martucci
- 1 September 1980
- journal article
- research article
- Published by The Endocrine Society in The Journal of Clinical Endocrinology & Metabolism
- Vol. 51 (3) , 611-615
Abstract
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.Keywords
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