Low Molecular Mass Aluminum Complex Speciation in Biofluids
Authors:
- 1 June 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Coordination Chemistry
- Vol. 23 (1-4) , 277-290
Abstract
Formation constants for the aluminum phosphate system and particle size analyses for solutions containing this material are reported. From a database of (i) the total ligand and metal concentrations in saliva, stomach juice, small intestinal fluid, milk, blood plasma and intravenous fluid, and (ii) physico-chemical constants for all feasible reactions involving low molecular mass complexes, a series of computer models was constructed and used to calculate the distribution of chemical species at equilibrium. The pie-diagrams of speciation indicate that some aluminum complexes exist as net-neutral charged species (which are potentially bioavailable) whereas others are charged and so are highly solvated and/or removed by the renal system. The chemical speciation knowledge produced in this research can be useful in researching aluminum intoxication, prevention and decontamination therapies.Keywords
This publication has 15 references indexed in Scilit:
- Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivoJournal of Inorganic Biochemistry, 1990
- PARENTERAL CITRIC ACID FOR ALUMINIUM INTOXICATIONThe Lancet, 1988
- RISKS OF SIMULTANEOUS THERAPY WITH ORAL ALUMINIUM AND CITRATE COMPOUNDSThe Lancet, 1988
- The binding of metal Ions by mercaptoacids. II. Formation constants for the complexes of mercaptosuccinate with Cd(II) and computer simulation of its ability to mobilize the low molecular weight fraction of Cd(II) in blood plasmaInorganica Chimica Acta, 1987
- Predicted chemical speciation of essential metals in digested foodInorganica Chimica Acta, 1986
- The use of glass electrodes for the determination of formation constants—II Simulation of titration dataTalanta, 1985
- Aluminium concentrations in the brain and bone of rate fed citric acid, aluminium citrate or aluminium hydroxideFood and Chemical Toxicology, 1984
- Gastrointestinal Absorption of Aluminum from Aluminum-Containing AntacidsNew England Journal of Medicine, 1977
- Computer simulation of metal-ion equilibria in biofluids: models for the low-molecular-weight complex distribution of calcium(II), magnesium(II), manganese(II), iron(III), copper(II), zinc(II), and lead(II) ions in human blood plasmaJ. Chem. Soc., Dalton Trans., 1977
- Ambivalent effect of protein binding on computed distributions of metal ions complexed by ligands in blood plasmaCellular and Molecular Life Sciences, 1976