Attenuation of Alcohol Preference in Alcohol‐Preferring Rats by a Novel TRH Analogue, TA‐0910

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Abstract
Experiments were performed to characterize the acute effect different doses of a novel thyrotropin-releasing hormone (TRH) analogue (TA-0910) on ethanol intake in rats. Selectively bred alcohol-preferring (P) rats received a single intraperitoneal injection of normal saline or 0.083, 0.25 and 0.75 mg/kg of TA-0910 at 9:30 AM, and their consumption of ethanol, water, and food was measured for hr. TA-0910 dose-dependently attenuated ethanol intake and commensurately increased water consumption. Only the highest dose TA-0910 increased the total caloric intake. TA-0910 did not affect the pharmacokinetics of ethanol. These findings indicate involvement of TRH systems in ethanol preference and suggest that centrally acting TRH analogues may be therapeutic in the treatment of alcoholism.

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