Oxidative steps during the biosynthesis of squalestatin S1
Authors:
Open Access
- 15 November 2018
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 10 (4) , 1227-1231
Abstract
Two enzymes of previously unknown function encoded by the squalestatin biosynthetic gene cluster from the fungus Phoma MF5453 catalyse a remarkable series of six consecutive oxidations to form the 4,8-dioxa-bicyclo[3.2.1]octane core of the squalestatins.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (INST 187/621-1)
This publication has 19 references indexed in Scilit:
- Double Oxidation of the Cyclic Nonaketide Dihydromonacolin L to Monacolin J by a Single Cytochrome P450 Monooxygenase, LovAJournal of the American Chemical Society, 2011
- In Vitro Precursor-Directed Synthesis of Polyketide Analogues with Coenzyme A Regeneration for the Development of Antiangiogenic AgentsOrganic Letters, 2009
- Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3Journal of the American Chemical Society, 2009
- Mechanism of Methyl Esterification of Carboxylic Acids by TrimethylsilyldiazomethaneAngewandte Chemie International Edition, 2007
- Efficient PCR-based gene targeting with a recyclable marker for Aspergillus nidulansFungal Genetics and Biology, 2006
- Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesisChemical Communications, 2004
- The Squalestatins: Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified AnaloguesJournal of Medicinal Chemistry, 1996
- Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and BBioorganic & Medicinal Chemistry Letters, 1995
- The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.The Journal of Antibiotics, 1992
- The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. III. Biosynthesis.The Journal of Antibiotics, 1992