Calcium‐activated, phospholipid‐dependent protein kinase activity and protein phosphorylation in HL60 cells induced to differentiate by retinoic acid

Authors:
Publisher website
Google Scholar
Abstract
Treatment of human promyelocytic (HL60) cells with retinoic acid for at least 48 h causes differentiation to more mature myeloid forms. Prior to commitment of cells to the myeloid pathway there is a marked increase in cytosolic calcium‐activated, phospholipid‐dependent protein kinase activity. This increase does not result from an intracellular redistribution of the enzyme. Concomitant with the increased enzyme activity there is enhanced phospholipid‐dependent phosphorylation of proteins of 29, 49, 52, 58, 68, 69, 120, 170, 200 and 245 kDa.

This publication has 13 references indexed in Scilit: