Leukopheresis therapy for severe infantile pertussis with myocardial and pulmonary failure

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Abstract
To describe an infant with severe pertussis successfully treated with leukopheresis. Case report. Pediatric intensive care unit of a children's hospital. Five-wk-old female with pertussis complicated by cardiorespiratory failure. Single leukopheresis treatment. Normalization of the white blood cell count and marked cardiorespiratory improvement after treatment; patient survived. Given the temporal association between treatment and improvement, we hypothesize that the markedly elevated white blood cell count has a major role in the cardiopulmonary compromise.

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