Collagen matrix stiffness influences fibroblast contraction force
- 28 July 2016
- journal article
- Published by IOP Publishing in Biomedical Physics & Engineering Express
- Vol. 2 (4) , 047002
Abstract
Cell-embedded hydrogel has been widely used as engineered tissue equivalents in biomedical applications. In this study, contraction force in human aortic adventitial fibroblasts seeded within a 3D collagen matrix was quantified by a novel force sensing technique. We demonstrate that contraction forces in cells treated with histamine are regulated by the gel stiffness in a linear manner. These findings provide novel insights into the design of collagen-based biomaterials for tissue engineering and clinical applications.Keywords
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