Gluten Challenge in Dermatitis Herpetiformis

Authors:
  • JLJonathan Leonard
    Jonathan Leonard
  • GHGerald Haffenden
    Gerald Haffenden
  • WTWilliam Tucker
    William Tucker
  • JUJoseph Unsworth
    Joseph Unsworth
  • FSFrances Swain
    Frances Swain
  • RMRobert McMinn
    Robert McMinn
  • JHJohn Holborow
    John Holborow
  • LFLionel Fry
    Lionel Fry
Publisher website
Google Scholar
Abstract
Dermatitis herpetiformis is characterized by an itchy blistering rash. The lesions are typically distributed over the elbows, knees, and buttocks. Histologically, the blister is situated between the epidermis and the dermis. The rash responds well to sulfone drugs, and the majority of cases are controlled with 100 mg of dapsone daily. Although the clinical picture, histologic findings, and response to sulfones are characteristic of the disease, the diagnosis can be made with certainty only by finding deposits of IgA in the papillary dermis of uninvolved skin by direct immunofluorescence.1 The role of gluten in the pathogenesis of dermatitis herpetiformis was . . .

This publication has 14 references indexed in Scilit: