Diagnosis of latent tuberculosis infection in healthy young adults in a country with high tuberculosis burden and BCG vaccination at birth
Authors:
- Alemnew F DagnewADAlemnew F Dagnew
- Jemal HusseinJHJemal Hussein
- Markos AbebeMAMarkos Abebe
- Martha ZewdieMZMartha Zewdie
- Adane MihretAMAdane Mihret
- Ahmed BedruABAhmed Bedru
- Menberework ChanyalewMCMenberework Chanyalew
- Lawrence YamuahLYLawrence Yamuah
- Girmay MedhinGMGirmay Medhin
- Peter BangPBPeter Bang
- T Mark DohertyTDT Mark Doherty
- Asrat HailuAHAsrat Hailu
Open Access
- 7 August 2012
- journal article
- Published by Springer Nature in BMC Research Notes
- Vol. 5 (1) , 415
Abstract
One third of the world’s population is thought to have latent tuberculosis infection (LTBI) with the potential for subsequent reactivation of disease. To better characterize this important population, studies comparing Tuberculin Skin Test (TST) and the new interferon-γ release assays including QuantiFERON®-TB Gold In-Tube (QFT-GIT) have been conducted in different parts of the world, but most of these have been in countries with a low incidence of tuberculosis (TB). The aim of this study was therefore to evaluate the use of QFT-GIT assay as compared with TST in the diagnosis of LTBI in Ethiopia, a country with a high burden of TB and routine BCG vaccination at birth.Keywords
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