Solution Blow Spun Mats with Beaded-Fiber Morphologies as a Drug Delivery System with Potential Use for Skin Wound Dressing

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Abstract
The regeneration of skin injuries can be aided by tissue engineering strategies, which enable the recovery of the structural and functional integrity of the damaged tissue. The Solution Blow Spinning (SBS) technique has attracted the attention of researchers due to the production of nanofiber mats in a continuous process, which exhibit high porosity and the ability to deliver drugs locally. The objective of this work was to produce and encapsulate ibuprofen in mats of PCL/PEG as a fast-acting analgesic drug delivery system. Initially, beaded nanofiber structures were produced from PCL solutions in chloroform at 8% (w/v) and PCL/PEG solutions in mass ratios of 2:1 and 1:1. The influence of the PEG concentration, gas pressure (compressed air), and solution injection rate on the fibers' morphology was analyzed by SEM. Then, the best condition for the formation of PCL/PEG beaded fiber structure was selected (1:1, 137.90 kPa, and 7.2 mL/h) for the fabrication of the mat containing ibuprofen at proportions of 5, 15, and 30% by polymer mass (PCL/PEG). The SBS-spun mats demonstrated a remarkable swelling capacity of approximately 400%, with bead presence enabling a gradual release of ibuprofen within the first 5 h. Additionally, the wound-healing assay confirmed that ibuprofen-loaded PCL/PEG8 mats significantly promoted NF migration, suggesting their potential to accelerate the wound-healing process.
Funding Information
  • Minist??rio da Ci??ncia, Tecnologia e Inova????o (308789/2020-6)
  • Funda????o Carlos Chagas Filho de Amparo ?? Pesquisa do Estado do Rio de Janeiro (NanoSade E-26/210.139/2019)
  • Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior (PROEX - 001)

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