Persulfidation is the mechanism underlying sulfide-signaling of autophagy
Open Access
- 7 June 2021
- journal article
- research article
- Published by Taylor & Francis in Autophagy
- Vol. 18 (3) , 695-697
Abstract
In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.Keywords
Funding Information
- European Regional Development Fund through the Agencia Estatal de Investigacion (PID2019-109785GB-I00)
- Junta de Andalucía
- Marie Skłodowska-Curie (834120 to A.A.)
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