The Enigma of Mammaglobin: Redefining the Biomarker Paradigm in Breast Carcinoma

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Abstract
The continuous evolution of cancer biology has led to the discovery of mammaglobin, a potential novel biomarker for breast carcinoma. This review aims to unravel the enigmatic aspects of mammaglobin and elucidate its potential role in redefining the paradigm of breast carcinoma biomarkers. We will thoroughly examine its expression in tumoral and peritumoral tissues and its circulating levels in the blood, thereby providing insights into its possible function in cancer progression and metastasis. Furthermore, the potential application of mammaglobin as a non-invasive diagnostic tool and a target for personalized treatment strategies will be discussed. Given the increasing incidence of breast carcinoma worldwide, the exploration of novel biomarkers such as mammaglobin is crucial in advancing our diagnostic capabilities and treatment modalities, ultimately contributing to improved patient outcomes.
Funding Information
  • Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (451-03-47/2023-01/200111, JP17/19)
  • Junior Project of the Faculty of Medical Sciences at the University of Kragujevac, Serbia (451-03-47/2023-01/200111, JP17/19)

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