Multiple specific contacts between a mammalian transcription factor and its cognate promoters
Authors:
- David GidoniDGDavid Gidoni
- William S. DynanWilliam S. Dynan
- Robert TjianRTRobert Tjian
- 1 November 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 312 (5993) , 409-413
Abstract
The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of these sequences forming close contacts with Spl. The clustered contacts fall on one strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters.Keywords
This publication has 18 references indexed in Scilit:
- Transcription from SV40-like monkey DNA sequencesNucleic Acids Research, 1984
- A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 geneCell, 1984
- The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoterCell, 1983
- SV40 deletion mutants lacking the 21-bp repeated sequences are viable, but have noncomplementable deficiencesNucleic Acids Research, 1983
- Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase IICell, 1983
- The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoterNucleic Acids Research, 1983
- Three segments from the monkey genome that hybridize to simian virus 40 have common structural elements.Molecular and Cellular Biology, 1981
- SV40 gene expression is modulated by the cooperative binding of T antigen to DNACell, 1981
- DNA sequences similar to those around the simian virus 40 origin of replication are present in the monkey genome.Proceedings of the National Academy of Sciences, 1981
- FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDESBiochemical Journal, 1963