Supplementary Figure S7. Impact of disease stage on PRO progression. The effect of disease stage on PRO progression was assessed using the SLP parameter. No statistically significant differences were observed across stages (ANOVA, p = 0.39) in the NSCLC Phase III clinical trial (NCT00532155). Subgroup sample sizes were as follows: Stage I, N = 24; Stage II, N = 10; Stage III, N = 111; and Stage IV or unknown stage, N = 223.