Macroscopic transport models for drugs and vehicles in cancer tissues

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Abstract
Modeling drug release in solid tumors is a convergence point between chemical engineering and medicine. Consequently, many studies have been conducted to unravel the mechanisms behind drug distribution after administration. In addition, several approaches have been explored, ranging from pharmacokinetic and pharmacodynamic models to microscopic transport models through macroscopic transport models. This chapter focuses on the latter, macroscopic transport models, and discusses how these models can predict the processes involved in drug delivery, in free form or vehicle transported. We start by presenting some of the differentiating physiological parameters in cancer tissues and then the main equations used for modeling, including fluid flow, mass transport, and cell uptake. Also, the use of some dimensionless parameters explaining the processes that control transportation will be examined. Lastly, the final section will explore the process employed for building geometries to simulate solid tumors, as well as current research being conducted on patient-specific simulations made using medical images.
Funding Information
  • Ministerio de Ciencia y TecnologÃ-a (PID2022-1405990B-I00)

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