The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens
Authors:
- Philippa MarrackPhilippa Marrack
- John W. KapplerJKJohn W. Kappler
- 1 October 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 335 (6193) , 796-801
Abstract
T cells with V beta 3+ alpha beta receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other V beta elements. Polymorphism in the major histocompatibility complex and/or the self-antigens that cause massive deletion of T cells using particular V beta elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.Keywords
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