Idiopathic Orthostatic Hypotension

Authors:
  • ASAlexander Schirger
    Alexander Schirger
  • EHEdgar A. Hines
    Edgar A. Hines
  • GMGeorge D. Molnar
    George D. Molnar
  • JTJuergen E. Thomas
    Juergen E. Thomas
Publisher website
Google Scholar
Abstract
Six patients with idiopathic orthostatic hypotension were studied for the effect and mode of action of 9-alpha-fluorohydrocortisone. In 5 patients satisfactory symptomatic control of the hypotension was achieved. In 1 patient it was twice demonstrated that the rise of blood pressure obtained within 48 hours after starting treatment with 9-alpha-fluorohydrocortisone was accompanied by increased sodium retention and potassium excretion, as measured by metabolic balance studies. On long-term observation, while the improvement in blood pressure was maintained, no major alterations in water and electrolyte balance persisted.