Low Rank Matrix Factorization Algorithm Based on Multi-Graph Regularization for Detecting Drug-Disease Association

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Abstract
Detecting potential associations between drugs and diseases plays an indispensable role in drug development, which has also become a research hotspot in recent years. Compared with traditional methods, some computational approaches have the advantages of fast speed and low cost, which greatly accelerate the progress of predicting the drug-disease association. In this study, we propose a novel similarity-based method of low-rank matrix decomposition based on multi-graph regularization. On the basis of low-rank matrix factorization with $L_{2}$ regularization, the multi-graph regularization constraint is constructed by combining a variety of similarity matrices from drugs and diseases respectively. In the experiments, we analyze the difference in the combination of different similarities, resulting that combining all the similarity information on drug space is unnecessary, and only a part of the similarity information can achieve the desired performance. Then our method is compared with other existing models on three data sets (Fdataset, Cdataset and LRSSLdataset) and have a good advantage in the evaluation measurement of AUPR. Besides, a case study experiment is conducted and showing that the superior ability for predicting the potential disease-related drugs of our model. Finally, we compare our model with some methods on six real world datasets, and our model has a good performance in detecting real world data.
Funding Information
  • National Natural Science Foundation of China (NSFC 62172296, 62172076, U22A2038)
  • Excellent Young Scientists Fund in Hunan Province (2022JJ20077)
  • Scientific Research Fund of Hunan Provincial Education Department (22A0007)
  • CCF-Tencent Open Fund (IAGR20220109)
  • Zhejiang Lab Open Research Project (K2022PE0AB07)
  • Zhejiang Provincial Natural Science Foundation of China (LY23F020003)
  • Municipal Government of Quzhou (2022D006)
  • Key Laboratory of Computational Science and Application of Hainan Province (JSKX202201)

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