Synthesis of Succinonitrile Derivatives by Homocoupling from Cyanohydrin Derivatives with a Low-Valent Titanium Reagent
- 20 January 2022
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 87 (5) , 3707-3711
Abstract
A method is described for synthesizing succinonitrile derivatives bearing alkyl or aryl substituents from cyanohydrin derivatives using low-valent titanium. The active species in this reaction is proposed to be a resonance hybrid of the TiIV nitrile enolate and TiIII alkyl radical.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology (S1511016)
- Japan Society for the Promotion of Science (18K05130)
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