Respiratory Syncytial Virus and Influenza A Infections in the Hospitalized Elderly

Authors:
  • CCColeen K. Cunningham
    Coleen K. Cunningham
  • WBWilliam H. Barker
    William H. Barker
  • RKRuth W. Kouides
    Ruth W. Kouides
  • JYJohn B. Yuen
    John B. Yuen
  • MMMarilyn Menegus
    Marilyn Menegus
  • LWLeonard B. Weiner
    Leonard B. Weiner
  • CBCynthia A. Bonville
    Cynthia A. Bonville
  • RBRobert F. Betts
    Robert F. Betts
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Abstract
Respiratory syncytial virus (RSV) infections in the institutionalized elderly have been described; however, there is little information on the impact of RSV infection on community-dwelling elderly. The purpose of this study was to determine the relative numbers of hospitalizations associated with RSV infection and compare the clinical manifestations with influenza A infection. Between November and April during 1989–1992, persons ⩾65 years old hospitalized with acute cardiopulmonary conditions or influenza-like illnesses were evaluated. Evaluation included viral culture, RSV antigen detection, and serologic analysis; 159 (10%) of 1580 had RSV infection and 221 (11%) of 2091 had influenza A. RSV and influenza A cases occurred simultaneously throughout the 3 years. Clinical manifestations were similar; however, patients with RSV infection were more likely to receive therapy for bronchospasm. Death rates were 10% and 6% for RSV infection and influenza A, respectively. RSV infection is the cause of serious disease in community-dwelling older persons.