An update on the H blood group system
Authors:
- 1 January 2019
- journal article
- Published by Walter de Gruyter GmbH in Immunohematology
- Vol. 35 (2) , 67-68
Abstract
This update of the H blood group system (Scharberg EA, Olsen C, Bugert P. The H blood group system. Immunohematology 2016;32:112–8) reports 11 new FUT1 null alleles: 8 causative for the H– phenotype (Bombay phenotype, O h ), 3 in para-Bombay cases, and 5 new FUT1 alleles causative for a weak H phenotype (para-Bombay, H+ w ). The H blood group system (International Society of Blood Transfusion system 18) consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells (RBCs) and in secretions. The H antigen is synthesized on the RBC surface by the FUT1 gene product fucosyltransferase 1. On epithelial cells and in body fluids, the H antigen is synthesized by the FUT2 gene product fucosyltransferase 2.Keywords
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