Markovnikov‐Selective Palladium Catalyst for Carbonylation of Alkynes with Heteroarenes
Authors:
- 2 August 2017
- journal article
- zuschrift
- Published by Wiley in Angewandte Chemie
- Vol. 129 (39) , 12138-12142
Abstract
A new class of palladium catalysts, based on heterocyclic diphosphines, was rationally designed and synthesized. Application of one of these catalysts allows novel Markovnikov‐selective carbonylation of non‐activated alkynes with heteroarenes to give the corresponding branched α,β‐unsaturated ketones in excellent yields (up to 97 %) and regioselectivities (b/l up to 99:1). In addition to heteroarenes, other common nucloephiles (alcohol, phenol, amine, and amide) furnish the desired carbonylation products smoothly in high yields.Keywords
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